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KMID : 0367419690100060009
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Journal of Korean Pediatric Society
1969 Volume.10 No. 6 p.9 ~ p.17
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Clinical Observation of Aplastic Anemia
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金慈煥/Kim, Ja Hwan
金寶卿/金義子/文永殷/尹德鎭/Kim, Bo Kyung/Kim, Yee Ja/Moon, Young Un/Yun, Duk Jin
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Abstract
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This paper deals with a group of 22 patients diagnosed at Severance Hospital between 1959 and 1965 as having aplastic anemia.
Age incidence in the group of patients was 7 to 14 years except for one case.
There was a striking defference in sex incidence, 16 cases were in males and 6 cases in females.
The chief complaints in 16 patients at admission were severe hemorrhage, purpure, and anemia.
The periperal blood was characterized by a pancytopenia, macrocytic, and normocytic in some patients. Coomb´s test was done in 6 of the 22 patients, none of whom showed positive findings.
Bone marrow showed hypocellularity(less than 20 per cent of the normal cellularity) and fatty infiltration.
The underlying causes of marrow insufficiency in 19 patients was not precisely defined, but Chinese drugs were suspected as causative agents in patients. In 2 patients Chinese drugs and Chlorampenicol were suspected. Chlorampenicol was deficitely the causative agent in 3 patients.
All the aplastic anemia patients were treated with tranfusion of blood, and corticosteroid combined with testosterone.
Fifteen of the patients ultimately died. Seven childrens are still living, 2 of them are recovered completely, four patients are clinically improved. One patient shows no response to treatment.
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